Detalhe da pesquisa
1.
Investigating Sulfoxide-to-Sulfone Conversion as a Prodrug Strategy for a Phosphatidylinositol 4-Kinase Inhibitor in a Humanized Mouse Model of Malaria.
Antimicrob Agents Chemother
; 62(12)2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30249687
2.
UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria.
Antimicrob Agents Chemother
; 62(9)2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29941635
3.
Potent Plasmodium falciparum gametocytocidal compounds identified by exploring the kinase inhibitor chemical space for dual active antimalarials.
J Antimicrob Chemother
; 73(5): 1279-1290, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29420756
4.
Synthesis and biological evaluation of aryl-oxadiazoles as inhibitors of Mycobacterium tuberculosis.
Bioorg Med Chem Lett
; 28(10): 1758-1764, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29680666
5.
Aminopyrazolo[1,5-a]pyrimidines as potential inhibitors of Mycobacterium tuberculosis: Structure activity relationships and ADME characterization.
Bioorg Med Chem
; 23(22): 7240-50, 2015 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26522089
6.
Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria".
Antimicrob Agents Chemother
; 62(11)2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30355750
7.
Benzobistriazinones and related heterocyclic ring systems as potent, orally bioavailable positive allosteric AMPA receptor modulators.
Bioorg Med Chem Lett
; 21(24): 7455-9, 2011 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22056742
8.
Benzotriazinone and benzopyrimidinone derivatives as potent positive allosteric AMPA receptor modulators.
Bioorg Med Chem Lett
; 21(20): 6170-5, 2011 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21889339
9.
Benzoheterocyclic Oxime Carbamates Active against Mycobacterium tuberculosis: Synthesis, Structure-Activity Relationship, Metabolism, and Biology Triaging.
J Med Chem
; 64(13): 9444-9457, 2021 07 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34138573
10.
Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts.
J Med Chem
; 64(4): 2291-2309, 2021 02 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33573376
11.
Lerisetron Analogues with Antimalarial Properties: Synthesis, Structure-Activity Relationship Studies, and Biological Assessment.
ACS Omega
; 5(12): 6967-6982, 2020 Mar 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-32258933
12.
Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model.
J Med Chem
; 63(21): 13013-13030, 2020 11 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33103428
13.
Optimisation of a series of potent, selective and orally bioavailable GlyT1 inhibitors.
Bioorg Med Chem Lett
; 19(8): 2235-9, 2009 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19318248
14.
Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria.
J Med Chem
; 61(13): 5692-5703, 2018 07 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29889526
15.
Antimalarial Lead-Optimization Studies on a 2,6-Imidazopyridine Series within a Constrained Chemical Space To Circumvent Atypical Dose-Response Curves against Multidrug Resistant Parasite Strains.
J Med Chem
; 61(20): 9371-9385, 2018 10 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-30256636
16.
Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγ null Mouse Model of Malaria.
J Med Chem
; 61(9): 4213-4227, 2018 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29665687
17.
2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization.
ACS Infect Dis
; 4(6): 954-969, 2018 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29522317
18.
Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure-Activity Relationship and Target Identification Studies.
J Med Chem
; 60(24): 10118-10134, 2017 12 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-29148755
19.
Evidence for a significant role of alpha 3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines.
J Neurosci
; 25(46): 10682-8, 2005 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-16291941
20.
Imidazo[1,2-a]pyrimidines as functionally selective and orally bioavailable GABA(A)alpha2/alpha3 binding site agonists for the treatment of anxiety disorders.
J Med Chem
; 49(1): 35-8, 2006 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-16392789